{"created":"2023-06-19T07:15:02.439818+00:00","id":1334,"links":{},"metadata":{"_buckets":{"deposit":"3ce61c46-6033-4f11-a05e-087439a8d46f"},"_deposit":{"created_by":12,"id":"1334","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1334"},"status":"published"},"_oai":{"id":"oai:tokoha-u.repo.nii.ac.jp:00001334","sets":["1:229"]},"author_link":["127","1851","1852","178"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"37","bibliographicPageEnd":"253","bibliographicPageStart":"239","bibliographic_titles":[{"bibliographic_title":"常葉大学教育学部紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Tokoha University Faculty of Education research review","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、環境汚染物質の増加に伴い、様々な疾患が増加し、重篤化しているのではないかと考えられている。そこで、これらの作用を抑制するような物質の探索を試みた。本研究では、緑茶、べにふうき、松葉に注目した。これまで多環芳香族炭化水素（PAHs）の１つであるbenz[a]anthracene（BaA）、及びその塩素置換体ClBaA が、乳がん細胞MCF-7 を増殖させる作用があることを報告したが、これらと植物葉を複合曝露した。BaA とClBaA は、濃度依存的に細胞増殖能を高めたが、緑茶とべにふうきの原液の添加により、細胞死が起こった。10 倍希釈では、増殖能を抑制する傾向が認められた。松葉の原液では、増殖能が大きく低下したが、細胞死を起こさなかった。また、BaA と松葉の組み合わせで、遺伝子発現レベルを解析した。pS2、CYP1A1、IL-6 に関して、松葉自体は発現レベルを上昇させないが、BaA による3 遺伝子の発現上昇を抑制した。従って、松葉にはBaA の作用を遺伝子レベルで抑える効果があることが考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18894/00001317","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"常葉大学教育学部","subitem_publisher_language":"ja"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12667974","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-434X","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久留戸, 涼子","creatorNameLang":"ja"},{"creatorName":"クルト, リョウコ","creatorNameLang":"ja-Kana"},{"creatorName":"KURUTO, Ryoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"久留戸","familyNameLang":"ja"},{"familyName":"クルト","familyNameLang":"ja-Kana"},{"familyName":"KURUTO","familyNameLang":"en"}],"givenNames":[{"givenName":"涼子","givenNameLang":"ja"},{"givenName":"リョウコ","givenNameLang":"ja-Kana"},{"givenName":"Ryoko","givenNameLang":"en"}],"nameIdentifiers":[{},{"nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000243874937"}]},{"creatorNames":[{"creatorName":"油目, 桃","creatorNameLang":"ja"},{"creatorName":"アブラメ, モモ","creatorNameLang":"ja-Kana"},{"creatorName":"ABURAME, Momo","creatorNameLang":"en"}],"familyNames":[{"familyName":"油目","familyNameLang":"ja"},{"familyName":"アブラメ","familyNameLang":"ja-Kana"},{"familyName":"ABURAME","familyNameLang":"en"}],"givenNames":[{"givenName":"桃","givenNameLang":"ja"},{"givenName":"モモ","givenNameLang":"ja-Kana"},{"givenName":"Momo","givenNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"櫻井, 正剛","creatorNameLang":"ja"},{"creatorName":"サクライ, セイゴウ","creatorNameLang":"ja-Kana"},{"creatorName":"SAKURAI, Seigo","creatorNameLang":"en"}],"familyNames":[{"familyName":"櫻井","familyNameLang":"ja"},{"familyName":"サクライ","familyNameLang":"ja-Kana"},{"familyName":"SAKURAI","familyNameLang":"en"}],"givenNames":[{"givenName":"正剛","givenNameLang":"ja"},{"givenName":"セイゴウ","givenNameLang":"ja-Kana"},{"givenName":"Seigo","givenNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大浦, 健","creatorNameLang":"ja"},{"creatorName":"オオウラ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"OHURA, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"大浦","familyNameLang":"ja"},{"familyName":"オオウラ","familyNameLang":"ja-Kana"},{"familyName":"OHURA","familyNameLang":"en"}],"givenNames":[{"givenName":"健","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-11"}],"displaytype":"detail","filename":"17久留戸涼子.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PDF","url":"https://tokoha-u.repo.nii.ac.jp/record/1334/files/17久留戸涼子.pdf"},"version_id":"f1948ad5-df5e-42fd-9528-f088a5e44ae2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"緑茶","subitem_subject_scheme":"Other"},{"subitem_subject":"べにふうき","subitem_subject_scheme":"Other"},{"subitem_subject":"松葉","subitem_subject_scheme":"Other"},{"subitem_subject":"BaA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ClBaA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"植物葉の多環芳香族炭化水素の作用に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"植物葉の多環芳香族炭化水素の作用に及ぼす影響","subitem_title_language":"ja"},{"subitem_title":"The Effects of Plant Leaves on the Action of Polycyclic Aromatic Hydrocarbons","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["229"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-11"},"publish_date":"2017-07-11","publish_status":"0","recid":"1334","relation_version_is_last":true,"title":["植物葉の多環芳香族炭化水素の作用に及ぼす影響"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-09-26T07:58:45.659622+00:00"}